Reck M, Rodríguez-Abreu D, Robinson AG, et al.Pembrolizumab versus chemotherapy for PD-L1–positive non–small-cell lung cancer.N Engl J Med.2016; Oct 9 [Epub ahead of print]. doi: 10.1056/NEJMoa1606774
Herbst RS, Baas P, Kim DW, et al.Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial.Lancet.2016;387(10027):1540-1550
Roach C, Zhang N, Corigliano E, et al.Development of a companion diagnostic PD-L1 immunohistochemistry assay for pembrolizumab therapy in non-small-cell lung cancer.Appl Immunohistochem Mol Morphol.2016;24:392-397
Dolled-Filhart M, Roach C, Toland G, et al.Development of a companion diagnostic for pembrolizumab in non-small cell lung cancer using immunohistochemistry for programmed death ligand-1.Arch Pathol Lab Med.2016. doi:10.5858/arpa.2015-0542-OA
Herbst RS, Soria JC, Kowanetz M, et al.Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature.2014; 515(7528):563-567
Tumeh PC, Harview CL, Yearley JH, et al.PD-1 blockade induces responses by inhibiting adaptive immune resistance.Nature.2014;515(7528):568-571
Hanahan D, Weinberg RA.Hallmarks of cancer: the next generation.Cell.2011;144(5):646-674
Keir ME, Butte MJ, Freeman GJ, Sharpe AH.PD-1 and its ligands in tolerance and immunity.Annu Rev Immunol.2008;26:677-704
Freeman GJ, Long AJ, Iwai Y, et al.Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.J Exp Med.2000;192(7):1027-1034
Dong H, Strome SE, Salomao DR, et al.Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.Nat Med.2002;8(8):793-800
Mu CY, Huang JA, Chen Y, Chen C, Zhang XG.High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation.Med Oncol.2011;28(3):682-688
Gettinger S, Herbst RS.B7-H1/PD-1 blockade therapy in non-small cell lung cancer: current status and future direction.Cancer J.2014;20(4):281-289
Brahmer JR, Tykodi SS, Chow LQ, et al.Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.N Engl J Med.2012;366(26):2455-2465
Topalian SL, Hodi FS, Brahmer JR, et al.Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.N Engl J Med.2012;366(26):2443-2454
Boland JM, Kwon ED, Harrington SM, et al.Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung.Clin Lung Cancer.2013;14(2):157-163
Chen YB, Mu CY, Huang JA.Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study.Tumori.2012;98(6):751-755
Velcheti V, Schalper KA, Carvajal DE, et al.Programmed death ligand-1 expression in non-small cell lung cancer.Lab Invest.2014;94(1):107-116
Garon EB, Rizvi NA, Hui R, et al.Pembrolizumab for the treatment of non-small cell lung cancer.N Engl J Med.2015;372(21):2018-2028